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July 19, 2018

Overbreeding of UK lab mice makes mockery of government pledge to reduce animal use in scientific research

Wasteful breed-to-kill cycle consumed 1.9 million animals in UK labs in 2017

Humane Society International/United Kingdom

  • Animals are needlessly being killed. istock

LONDON—Home Office statistics published today detailing the United Kingdom’s use of animals in scientific procedures in 2017 [1] have been sharply criticised by Humane Society International/UK as exposing the government’s complacency and continued, embarrassing failure to use its regulatory and research funding powers to curb out of control animal breeding by universities and other laboratories.

According to the statistics, 3.79 million procedures on living animals were authorised by UK authorities in 2017, of which almost 2 million (half the total number) were associated with the production of genetically altered animals. Surplus animals from continuous breeding programmes are not used for any specific testing or research purpose, and as such their production cannot be claimed to advance scientific knowledge or medical progress. The current trend flies in the face of a July 2011 government commitment by then the Parliamentary Under-Secretary of State for the Home Department to work to reduce the use of animals in scientific research [2].

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Troy Seidle, vice president for Research & Toxicology at HSI, said: “It is disgraceful that seven years after the UK government’s pledge to reduce animal use in scientific research, the animal body count remains high year on year, with no meaningful or effective strategy in place to address the number one cause: out-of-control breeding of engineered animals. Once again, Humane Society International calls on the government to require increased use of cryopreservation, the freezing of sperm or embryos, to short-circuit this appalling breed-kill cycle. As the department responsible for authorising animal experiments, the Home Office has all the authority it needs to require universities and other institutions to adopt more efficient strategies to minimise over-production of genetically modified animals -- all that’s missing is the motivation to act.”

HSI tabled a Parliamentary question in September last year to enquire what steps the Home Secretary would be taking to reduce this overbreeding of genetically altered animals in the UK [3]. The response was bland, generic and ultimately reveals the lack of governmental appetite to meet this issue head-on, culminating in the breeding and death of almost 2 million animals this year. The Home Office publication of an Assessment Framework for the Efficient Breeding of Genetically Altered Animals [4] may appear to address the issue, but the lack of enforcement of this ‘advisory’ document means that it is essentially toothless and merely pays lip service to the overall mandate of the European Directive 2010/63/EU to replace animal use in scientific research and to the coalition government’s pledges made in 2010 to reduce the use of animals in scientific research [5].

Facts:

  • Despite the ever-increasing growth in animal procedures, there is no corresponding increase in human therapeutics making it to the clinic, with both the European Medicines Agency and US Food and Drug Administration approving lowest number of new drugs in 2016 [6,7].
  • Some genetic mutations cause catastrophic defects, such as mice born with shortened limbs, with no limbs, with the front of their head missing [8]. If the mice survive birth, they could have significant developmental defects affecting their limbs, eyes, brain or hair; they may be predisposed to tumour formation, or they could be subjected to deliberate, repeated and ultimately fatal infections to assess the impact of the mutation on their response [9].
  • Advances in gene sequencing and phenotypic analysis in humans is ushering in the era of precision medicine, and focused funding and efforts on human-relevant technologies like these are more likely to provide disease understanding and much-needed new treatments [10].

ENDS

Contact: Dr Lindsay Marshall, 07719 531 675, lmarshall@hsi.org

Notes to editors:

1. 2017 Home Office statistics: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/724611/annual-statistics-scientific-procedures-living-animals-2017.pdf

2. https://publications.parliament.uk/pa/cm201011/cmhansrd/cm110718/wmstext/110718m0001.htm#1107182000388

3. https://www.parliament.uk/business/publications/written-questions-answers-statements/written-question/Commons/2017-09-04/6958/

4. https://org.uib.no/dyreavd/Documents/GAA%20tool.pdf

5. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/277942/bis-14-589-working-to-reduce-the-use-of_animals-in-research.pdf

6. https://www.fda.gov/drugs/developmentapprovalprocess/druginnovation/ucm483775.htm

7. Mullard, A. (2017). EMA drug approval recommendations. Nat Rev Drug Discov. 16;77. doi:10.1038/nrd.2017.17

8. Turgeon B, Meloche S (2009). Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases. Physiol Rev. Jan;89(1):1-26. doi: 10.1152/physrev.00040.2007

9. Holtzclaw JD, et al. (2004). Enhanced pulmonary and systemic response to endotoxin in transgenic sickle mice. AJRCCM. 169(6)2004.

10. Aronson SJ, Rehm, HL (2015). Building the foundation for genomics in precision medicine. Nature. 526: 336-342. doi:10.1038/nature15816

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